Targeting NDM-producing ‘superbugs’: optimising novel combinations with ‘old’ polymyxins using pharmacological, molecular imaging and systems biology approaches

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1046561

Funding Status
Closed

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Funded Activity Summary

Rapid global spread of so-called NDM-producing bacterial ‘superbugs’ is presenting a major medical challenge. Without new antibiotics under development, polymyxin is becoming the only effective antibiotic. Unfortunately we recently revealed that treatment with polymyxin alone can rapidly lead to resistance in NDM-producing ‘superbugs’. This project will employ new tools to optimise rational polymyxin combinations, thereby providing urgently needed information to clinicians for treating these very problematic infections.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $582,732.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmacology and Pharmaceutical Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antibiotic therapy | antimicrobial resistance | electron microscopy | molecular imaging | pharmacodynamics | pharmacokinetics | systems biology

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