Twist-1 inhibits MSC osteoblast differentiation during osteoporosis via direct regulation of the Wnt signalling pathway

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1046053

Funding Status
Closed

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Funded Activity Summary

There is a predicted dramatic increase in the number of orthopaedic related problems that require surgical intervention and rehabilitation therapy in the coming decade associated with higher incidences of bone diseases as a consequence of an aging population. This proposal seeks to determine whether the transcription factor, Twist-1 plays a central role in regulating the growth and differentiation of skeletal progenitors during bone loss following the onset of osteoporosis.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $482,704.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bone cells | fracture repair | osteoporosis | stem cell biology | stem cells

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