Synovial macrophages and T-cells are therapeutic targets in osteoarthritis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1045890

Funding Status
Closed

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Funded Activity Summary

Osteoarthritis (OA) is the most widespread musculoskeletal disease in Australia and there are currently no therapies that halt disease progression. Specific inflammatory events play a pivotal role in initiating and driving OA progression. In this study we will define the specific inflammatory cells involved in OA, how and why they change with time, and which can be targeted to stop disease onset and development. This will provide the platform for initiating human clinical trials.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $658,761.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Rheumatology and Arthritis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

T cell activation | animal model | immunotherapy | macrophage activation | osteoarthritis | synovitis | translational research

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