Intergenerational transmission of gender-specific metabolic disease for offspring born small: maternal, paternal and embryonic roles

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1045602

Funding Status
Closed

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Funded Activity Summary

This proposal addresses the underlying metabolic health consequences of poor embryo and growth of the baby across generations. We will define mechanisms by which a poor functioning placenta during a rat mother’s pregnancy programs her offspring born small to transmit gender-specific diseases to the next generation. We will identify mechanistic pathways involved, specifically the relative contributions of maternal and paternal germ lines and adverse maternal adaptations to pregnancy for females born small.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $689,050.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Foetal Development and Medicine

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

embryo | maternal and child health | metabolic disease | placental insufficiency | pregnancy

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