Do ‘classical’ or ‘oxidative’ UVR-induced DNA adducts drive melanoma induction after ultraviolet radiation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1045534

Funding Status
Closed

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Funded Activity Summary

There is debate about the mechanisms by which sun exposure influences melanoma development. This leads to difficulties in formulating adequate sunscreens and guidelines for safe levels of exposure. We will elucidate the critical UV-induced DNA adducts that are necessary for MM development. This will introduce experimental evidence into the debate about sun exposure and melanoma. The use of post sunburn creams containing enzymes which rapidly remove the dangerous DNA adducts will be indicated.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $335,757.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology and Carcinogenesis not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA damage | melanoma | skin cancer | sun protection | ultraviolet (UV) radiation

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