Understanding the role of host Arih2 in defence against viral infection and disease pathogenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1045532

Funding Status
Closed

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Funded Activity Summary

A set of proteins, called E3 ligases, modulate many aspects of immunity. Arih 2 is a novel E3 ligase that limits immune cell activation to maintain the immune system in a quiescent state. The details of how Arih2 functions and its role in immunity to chronic overwhelming infection are the focus of this study. The insights gained from these studies have important implications for our understanding of how immune responses can be promoted during infection or halted in autoimmunity.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $537,737.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Virology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

T cell activation | autoimmunity | cell signalling | hepatitis B infection | human immunodeficiency virus (HIV) | immune modulation | immunity | infection | tuberculosis | virus pathogenesis

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