ALS4 mice show TDP-43 protein mislocalization in motor neurons characteristic of sporadic ALS patients; suggesting this model is likely to reveal important patho-mechanistic disease insights

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1045520

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

SETX gene mutations cause an inherited motor neurone disease (MND) known as ALS4. Our current understanding of MND was revolutionized by the discovery that a protein known as TDP-43 is the main component of protein accumulations found in dying human motor neurones. We have generated a unique mouse model of ALS disease that will be useful for research purposes, but may also prove effective for drug testing.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $108,466.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurology and Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

RNA binding proteins | RNA processing | aggregation | molecular basis of disease | molecular markers | molecular neuroscience | neurodegenerative disorders | neuronal death | neuronal survival

Related Links