Vaccine discovery for human mucosal pathogens: identifying novel vaccine antigens that are stably expressed during host interactions, using analysis of cell-contact and phasevarion mediated expression profiles

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1045235

Funding Status
Closed

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Funded Activity Summary

The control of several human pathogens depends on vaccine development due to antibiotic resistance and the devastating outcome of infection. This work aims to identify new vaccine targets for diseases including gonorrhoae, ear infections, meningitis and sepsis, based on proteins required for interaction with human cells. Proteins that are randomly switched on and off in these bacteria will also be studied to better understand disease and to rule out variably expressed genes from new vaccines.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2017

Funding Scheme: Career Development Fellowships

Funding Amount: $418,482.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Moraxella catarrhalis | Neisseria gonorrhoeae | Neisseria meningitidis | antibody | host/pathogen interaction | microbial pathogenesis | vaccine candidate molecules | virulence factors

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