Determining the causes of congenital vertebral defects

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1044543

Funding Status
Closed

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Funded Activity Summary

Many birth defects cause vertebral malformations along the spinal column. These originate as the fetus forms, and we have previously shown that some of these are caused by gene mutation and/or environmental factors during gestation. However, the origins of many such defects remain unexplained. We will examine the DNA of a large number of patients to find more genes causing such defects. We will also test if these new genes predispose a fetus to being more susceptible to environmental influences.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $956,136.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Notch signalling pathway | birth defect | developmental biology | embryonic development | gene-environment interaction | genetic susceptibility | hypoxia | mouse models | zebrafish

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