IRON EXPORT PROTEIN FAILURE IN PARKINSONISM AND DEMENTIA

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1044542

Funding Status
Closed

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Funded Activity Summary

We recently discovered a novel relationship between the Alzheimer’s amyloid precursor protein (APP) and tau, and that both proteins play a role in regulating iron levels in the brain. We predict that a loss or multiple failures in these iron-regulating systems could foster a toxic iron accumulation in brain, leading to the development of diseases with dementia such as Alzheimer’s and Parkinson’s diseases. We hope to gain a better understanding of their mechanism of action and propose that this pathway is a target for therapeutic intervention.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $843,352.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurology and Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | Parkinson disease | amyloid beta-protein | amyloid precursor protein | disease mechanisms | drug targeting | frontotemporal dementia | iron overload | iron transport | microtubule associated protein (MAP)

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