Selective targeting of microbes by peptides of the innate immune system.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1044327

Funding Status
Closed

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Funded Activity Summary

Cytolytic antimicrobial peptides (AMPs) are key components of the innate immune system of many organisms including man. They act by disrupting the outer membranes of bacteria, fungi and enveloped viruses. These simple peptides are highly specific and increasingly seen as a new source of antibiotic agents capable of combating the rising resistance to current drugs. Our aim is to determine the mechanism by which cytolytic AMPs act and to understand the factors that give rise to membrane and cell specificity.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $626,644.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antimicrobial resistance | antimicrobial therapy | computer simulation | innate immunity | membrane lipids | membranes | molecular modelling | nosocomial infections | nuclear magnetic resonance (NMR) spectroscopy | peptides

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