Apoptosis signal-regulating kinase 1 (ASK1) is a major pathway of stress-induced renal injury in different types of progressive kidney disease.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1044289

Funding Status
Closed

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Funded Activity Summary

Oxidative stress plays an important role in progressive kidney disease. We have identified a stress-activated mechanism (the ASK1 pathway) through which oxidative stress may cause kidney disease. We will perform preclinical studies in models of different types of kidney disease with an ASK1 inhibitor drug and genetically modified mice. These studies will provide new insights into the pathogenesis of kidney disease and will determine the potential of ASK1 as therapeutic target in kidney disease.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $678,865.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nephrology and Urology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

diabetic nephropathy | glomerular inflammation | glomerulosclerosis | kinase inhibitors | pathogenic mechanisms | renal interstitial fibrosis | signalling pathways

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