The role of PI 3-kinase p110beta in regulating thrombus porosity

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1044214

Funding Status
Closed

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Funded Activity Summary

Blood clots blocking blood flow to the brain (stroke) are a major cause of death and disability. Safety concerns limit the use of current therapies to a small subset of patients, and there is an urgent need to identify safer, more effective drugs. Our studies show that inhibitors of the enzyme PI3Kbeta increase the breakdown of blood clots, without increasing bleeding risk. Our preliminary results raise the possibility that PI3Kbeta inhibitors may represent a safe and effective new approach for the treatment of stroke.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $518,394.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

ischaemic stroke | platelets | signalling pathways | thrombolysis | thrombolysis treatment | thrombosis

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