Optimising efficacy of a peptide derived against the alpha-interacting domain of the L-type calcium channel in reduction of ischemia-reperfusion injury

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1043978

Funding Status
Closed

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Funded Activity Summary

A heart attack is associated with an increase in free radicals and calcium in heart muscle cells. The function of the L-type calcium channel, a protein responsible for calcium entry into cells, is altered by free radicals and this contributes to the development of heart disease. We now have considerable proof of concept that a peptide derived against the L-type calcium channel can decrease heart injury. We will optimise efficacy and delivery of the peptide to prevent heart failure.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $405,063.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

calcium | calcium channels | free radicals | heart attack | hypertrophy

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