Mitochondrial sirtuins, energy metabolism and insulin action

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1043779

Funding Status
Closed

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Funded Activity Summary

Post-translational modification of lysine residues has a major influence on protein function. Many mitochondrial proteins are affected by lysine modifications and recent work has described a role for sirtuin enzymes in regulating these processes. This proposal will investigate whether targeted increases in sirtuin activity can improve mitochondrial function and insulin action in mouse models of obesity and insulin resistance.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $582,925.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

energy metabolism | insulin action | mitochondrial function | oxidative stress | protein modification

Related Links