Determining modes of binding and activation of complex G-protein coupled receptor targets

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1043750

Funding Status
Closed

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Funded Activity Summary

The peptide hormones relaxin is currently in a Phase III trial for the treatment of heart failure. However the peptide is not a good drug as it can't be taken orally and is very expensive to produce. We will study the interaction of relaxin and the related peptide INSL3 with their cell surface receptors and the mechanisms by which the receptors function. The knowledge gained will aid in the design of smaller, more potent and orally active forms of relaxin which will be able to be used as drugs for the treatment of heart failure.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $620,399.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Basic Pharmacology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G protein-coupled receptors | drug targeting | molecular pharmacology | nuclear magnetic resonance (NMR) spectroscopy | regulatory peptides

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