Mechanism of protection of islet beta cells from T1D by heparan sulfate

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1043284

Funding Status
Closed

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Funded Activity Summary

Type 1 diabetes (T1D) is an autoimmune disease which destroys the insulin-producing beta cells in the pancreas. Current insulin therapy does not prevent the development of serious secondary complications. We have discovered that beta cells require a complex sugar (heparan sulfate; HS) for their survival and that T1D is prevented when an enzyme, heparanase, that degrades HS is inhibited. Understanding these mechanisms will identify new therapeutic strategies for preventing T1D progression.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $602,453.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autoimmunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

NOD mouse | diabetes mellitus | heparan sulfate | heparanase | islets of Langerhans

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