Regulation of inflammation and coagulation by microparticles containing SerpinB2

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1043104

Funding Status
Closed

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Funded Activity Summary

SerpinB2 is a protein that is abundant during many types of inflammation. However, what this protein actually does remains an enigma. We have found that SerpinB2 is associated with microparticles; small particles found in everyone’s blood, that are used by cells to communicate with each other. We believe inappropriate levels of SerpinB2 on these microparticles change both inflammation and blood clotting; a contention with implications for several diseases including pre-eclampsia and cancer.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $594,133.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

haematology | inflammation | macrophage biology | membrane biology | platelet function | serpin | thrombosis

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