Chronic TLR9 activation as a mechanism for granulomatous reaction in the cornea

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1042612

Funding Status
Closed

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Funded Activity Summary

Corneal opacities due to microbial infections are a major cause of blindness globally. Our novel data show that the presence of viral/bacterial DNA in the cornea induces formation of multinucleated giant cells, which are hallmarks of granulomatous reaction commonly seen in viral-induced corneal disease. Understanding the mechanisms and kinetics of macrophage differentiation in the inflamed cornea may lead to novel treatments for chronic inflammatory conditions in the eye and in other organs.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2017

Funding Scheme: Project Grants

Funding Amount: $283,416.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Optometry and Ophthalmology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

corneal scarring | corneal wound healing | inflammation | innate immunity | macrophage activation

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