Generating an effective vaccine response against the intrinsically unstructured malaria antigen Merozoite Surface Protein 2

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1042520

Funding Status
Closed

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Funded Activity Summary

The malaria surface protein MSP2 is a promising candidate for inclusion in a malaria vaccine, having shown evidence of protection in phase IIb studies. Our goals are to identify the structural basis for the differential induction of human immune responses to native and recombinant MSP2 and to utilise this information to generate an MSP2 vaccine able to evoke a more effective anti-malarial response.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $678,774.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antibody engineering | epitopes | immune response | malaria vaccine | membrane protein | protein biochemistry | protein conformation

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