How the Bcl-2 protein family controls apoptosis and impacts on cancer development and therapy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1041797

Funding Status
Closed

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Funded Activity Summary

Impaired cell death (apoptosis) is now recognized as an important step towards cancer and a major barrier to effective therapy. The discoveries on apoptosis by Professor Jerry Adams and colleagues have galvanized the search for drugs that engage the cell’s apoptotic machinery as a new way to treat cancer. His proposed studies aim to clarify how apoptosis is controlled and how the control goes awry in cancer, and to determine how such drugs can be most effectively used to improve cancer treatment.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2017

Funding Scheme: Research Fellowships

Funding Amount: $850,346.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bcl-2 | anti-tumour drugs | apoptosis | drug action | mitochondria | oncogenesis | protein complexes | protein structure

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