Microenvironmentally Induced Acute Lymphoblastic Leukemia Cell Quiescence and Chemotherapy Evasion

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1041614

Funding Status
Closed

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Funded Activity Summary

Although almost all patients with ALL achieve a remission, a proportion of children and the majority of adults relapse following treatment. Relapse occurs as a result of a small number of malignant cells that survive chemotherapy. We have identified a population of quiescent cells that could represent this population. We believe this population is defined by its location in the bone marrow. This project will characterize this population and determine whether it is protected from chemotherapy.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $672,885.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematological Tumours

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

chemotherapy | leukaemia | microenvironment | relapse prevention | stem cell biology

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