Targeting small airways to overcome resistance to therapy in asthma

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1041575

Funding Status
Closed

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Funded Activity Summary

There is a pressing need to overcome resistance to current therapies for severe asthma. Targetting inflammation-induced changes in small airway contraction offers an alternative strategy. We have identified a novel bronchodilator that relaxes maximally contracted mouse small airways when current treatment is ineffective. We will demonstrate its efficacy in animal models mimicking key features of human asthma, and define new ways to improve outcomes in poorly-controlled asthma.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $531,045.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Basic Pharmacology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

airway function | airway smooth muscle | animal model | asthma | bronchoconstriction | calcium signalling | inflammation | novel therapeutic agents | nuclear receptors | steroids

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