How do small extracellular vesicles contribute to the development of prion disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1041413

Funding Status
Closed

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Funded Activity Summary

Prion diseases are transmissible neurodegenerative disorders associated with the misfolding of the prion protein. This proposal will investigate how cells release the infectious agent responsible for prion diseases in small nanovesicles known as exosomes. We will characterise the novel processed forms of the proteins involved in these two neurodegenerative diseases within the exosomes and investigate whether the genetic content of exosomes has diagnostic potential.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $563,897.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

nanotechnology | neurodegenerative disorders | neurogenetics | prion diseases | vesicle trafficking

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