Activating T cell tolerance to prevent preeclampsia

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1041335

Funding Status
Closed

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Funded Activity Summary

Preeclampsia is a leading cause of prematurity and low birth weight in babies. There is evidence that preeclampsia originates with inadequate adaptation in the mother’s immune system to protect the placenta from immune attack. In mice we will investigate how events at conception activate immune tolerance, and define how the male partner contributes. In women, we will determine whether similar processes control the immune response in pregnancy, and whether this is faulty in preeclampsia.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $632,000.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Obstetrics and Gynaecology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cytokines | inflammation | leukocytes | mouse models | placenta | pre-eclampsia | pregnancy | regulatory T cells | reproductive immunology | uterus

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