Male-female sperm signalling - a novel pathway for peri-conceptual health?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1041332

Funding Status
Closed

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Funded Activity Summary

This project will investigate a new biological process in reproduction, whereby sperm delivered to the cervix at coitus transmit signalling molecules called microRNAs that influence the female immune response, to increase the chances of conception and pregnancy. We will define the molecular details of this signalling pathway in mouse models, and then determine whether human sperm have a comparable function in ‘priming’ the female body to conceive.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $674,920.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Reproduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cytokines | endometrium | female reproduction | infertility | male reproduction | microrna | regulatory T cells | reproductive immunology | sperm function | uterus

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