Roles of Cascades of Transforming Growth Factor-beta and Matrix Metalloproteinases in the Impact of Cancer Stem Cells on the Neoplasm Formation of Oral Squamous Cell Carcinoma.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1039888

Funding Status
Closed

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Funded Activity Summary

Failure of treatment of oral cancer patients is because the specific cancer cells escape from chemo-radiotherapy. These cells feature self-renew and fast growth, which are called cancer stem cells (CSC). We will test our hypothesis “the genes of TGF-?1 and MMP initiate CSCs” using our cell-mouse models to arrest cancer progression, and verify the impact of CSC on cancer formation. This study is critical to know how to arrest CSC and offer an opportunity to develop a targeted anti-cancer therapy.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Postgraduate Scholarships

Funding Amount: $81,793.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

aged health | animal model | biomarkers | cancer cell biology | cancer metastasis | carcinogenesis | cytokines | oral health | oral pathology | signalling pathways

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