Improving repair in dystrophic muscles by targeting ADAMTS5 activity and connective tissue remodeling

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1039718

Funding Status
Closed

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Funded Activity Summary

In muscle diseases such as muscular dystrophy degeneration exceeds its capacity to repair. Connective tissue remodelling facilitates the repair process; however the mechanisms by which it does this are poorly defined. This Project examines the role of connective tissue turn-over during muscle repair. It is anticipated that new insights into muscle regeneration will be gained to underpin development of therapeutics that promote muscle repair in skeletal muscle wasting diseases.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Postgraduate Scholarships

Funding Amount: $95,313.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

muscular dystrophy | protease | proteoglycans | regeneration | skeletal muscle

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