The effect of defective iron handling on immune function and Pseudomonas aeruginosa infection in the cystic fibrosis lung

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1039309

Funding Status
Closed

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Funded Activity Summary

In this research higher degree I will study the effects of iron on airway sepsis in cystic fibrosis (CF), with a particular focus on the major pathogen Pseudomonas aeruginosa. Increased concentrations of iron have been described in the CF lung, and CF airway epithelial cells display abnormal iron handling which facilitates P. aeruginosa growth. I will explore imposed iron limitation combined with conventional antibiotics as a new therapeutic strategy for treatment of chronic airway infection.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: NHMRC Postgraduate Scholarships

Funding Amount: $97,213.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Pseudomonas aeruginosa infection | bacterial biofilm | bacterial genetics | bacterial virulence factors | bronchiectasis | cystic fibrosis | inflammatory mediators | iron chelators | iron metabolism | neutrophils

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