Signal integration during the early B cell/CD4+ T cell interactions in T-dependent antibody responses

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1038881

Funding Status
Closed

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Funded Activity Summary

Effective humoral immunity results from the complex interaction of B and T lymphocytes. STAT3, CD40L, SAP and ICOS are molecules that are involved in this interaction. Genetic mutations of these molecules result in well defined primary immunodeficiencies underscoring their importance. This study aims to characterise the integration of these early signals as well as other inputs that B cells receive and characterise the CD4+ cells that provide this help.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2017

Funding Scheme: Postgraduate Scholarships

Funding Amount: $128,783.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

autoimmunity | germinal centre | humoral immunity | immunodeficiency | immunoglobulin (Ig) | immunology | lymphocytes | signalling

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