The mechanisms of SIV entry of follicular helper T cells

Funding Activity

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Funded Activity Summary

Follicular helper T (Tfh) cells are a type of immune cells essential in antibody production. Preliminary data shows that SIV infects macaque Tfh cells. In this project, we will investigate the mechanisms by which SIV enters into Tfh cells, and test the susceptibility of human Tfh cells to HIV-1 infection ex vivo. This project will enable understanding of the fate of Tfh in HIV infection and its role in HIV host defense and it may facilitate the design of vaccine against HIV.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Postgraduate Scholarships

Funding Amount: $95,313.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

T cell immunity | T cell memory | T cell subset | human immunodeficiency virus (HIV) | molecular virology