Lipotoxicity, mitochondrial dysfunction and the pathogenesis of heart failure

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1037603

Funding Status
Closed

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Funded Activity Summary

Heart failure (HF) is the most common basis for hospitalisation or cardiac death despite improved treatment options. Impaired energy generation within heart muscle is important in causing HF, but little is known about this process. I plan to investigate the effects of fatty acid overload, as occurs in obesity and/or diabetics, on cardiac energy generation. Then, I'll explore the benefits of limiting fatty acids during heart surgery, in order to help in understanding the causes of HF, and the benefits of new, energy-conserving treatments

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2017

Funding Scheme: Early Career Fellowships

Funding Amount: $454,358.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

diastolic dysfunction | fatty acids | heart failure | mitochondrial function | mitochondrial respiration | mouse models | obesity | reactive oxygen species (ROS)

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