The role of sterols in amyloid toxicity

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1037262

Funding Status
Closed

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Funded Activity Summary

Alzheimer's, Huntington's and Parkinson's diseases involve the formation of protein aggregates, termed amyloid. The formation of amyloid leads to cell death and neurodegeneration. The most important cellular events perturbed by the formation of amyloid aggregates are unclear. Recent evidence suggests that sterols (including cholesterol) have an important role in cellular toxicity. This study will examine the molecular basis for this, enhancing our understanding of the amyloid diseases and could suggest novel therapeutic avenues.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2017

Funding Scheme: Early Career Fellowships

Funding Amount: $373,235.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

amyloid | lipid biochemistry | protein aggregation | protein binding | protein conformation | protein interactions

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