The negative transgenerational impacts of paternal obesity are inherited through aberrant methylation and microRNA conetent of germ cells.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1036561

Funding Status
Closed

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Funded Activity Summary

We have shown that obese fathers have reduced sperm function that negatively impacts upon their offspring’s health. But we do not understand the underlying alterations to sperm DNA that cause offspring to inherit poor health from an obese father, and whether these offspring also exhibit the same alterations. My project aims to identify alterations made to sperm DNA and RNA caused by obesity that are inherited by the next generation, ‘programming’ them for poor metabolic and reproductive health.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Early Career Fellowships

Funding Amount: $307,946.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Reproduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

epigenetics | male infertility | male reproduction | metabolic disease | obesity | programming | reproductive health

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