The role of CYP2E1 in ethanol-mediated protein damage and its impact on proteolytic processing in the ER

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/103605

Funding Status
Closed

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Funded Activity Summary

Alcoholic liver disease (ALD) is the primary factor leading to mortality in chronic alcohol abusers. Alcoholic patients possess antibodies to damaged proteins in their bloodstreams, which indicates an underlying level of oxidative damage is occurring in their livers. The antibodies to these damaged proteins could trigger the destruction of liver cells. Alternatively, the damaged proteins themselves could result in cell death because of the way they are degraded in a particular compartment of the cell, the endoplasmic reticulum (ER). An enzyme, CYP2E1, has been demonstrated to produce the types of chemicals that damage proteins and it is significantly increased in the liver by alcohol consumption. The current scientific proposal is aimed at determining whether CYP2E1 induction by ethanol contributes to ALD by perturbing the normal cellular disposal of damaged proteins in the ER.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $179,239.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oral and maxillofacial surgery

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Alcohol associated autoimmunity | Alcoholic liver disease | CYP2E1 | Ethanol and organic solvents | Oxidative stress | Proteasomes | Protein damage in the endoplasmic reticulum | ubiquitin and ubiquitinating enzymes

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