The role of phosphorylation and signalling for invasion of Plasmodium falciparum into human erythrocytes.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1035715

Funding Status
Closed

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Funded Activity Summary

The intracellular signals that govern Plasmodium falciparum malaria invasion of the red blood cell are poorly understood. It is likely calcium dependent phosphorylation leads to recruitment and activation of a cascade of proteins. This study combines a break-through in purification of viable P. falciparum merozoites with proteomic analysis of phosphorylation states to assess intracellular signalling. It is expected the processes identified will be unique to P. falciparum and targetable by drugs.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Early Career Fellowships

Funding Amount: $307,946.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Parasitology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

intracellular signalling | invasion | malaria | merozoite | phosphorylation | proteomics

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