A targeted nutrient-depletion approach to tackle prostate cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1035693

Funding Status
Closed

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Funded Activity Summary

Prostate cancer is the most prevalent male specific cancer, and has a similar incidence to breast cancer in women. We are studying the role of protein pumps that control the amount of nutrients taken into and out of cancer cells. We are aiming to structurally determine LAT1 and LAT3, two nutrient pumps important for cancer progression, and to use these structures as a platform for drug design where the intention is to drugs 'starve’ the cancer by restricting nutrient uptake.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Career Development Fellowships

Funding Amount: $408,388.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

X-ray crystallography | drug discovery | membrane protein | membrane transport | structural biology

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