Structure and composition of the pre-T cell receptor-CD3 complex

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1035636

Funding Status
Closed

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Funded Activity Summary

In order to recognize a wide variety of pathogens, humans produce many different T cell receptors (TCRs) by the process of gene-rearrangement. However, gene-rearrangement may not always lead to a functioning TCR. We are studying the pre-TCR protein that is responsible for monitoring the success of gene-rearrangement and is thus essential for the formation of a robust immune system. Understanding pre-TCR function will lead to new treatments for immune related diseases.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Early Career Fellowships

Funding Amount: $307,946.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

T cell receptor | acute lymphoblastic leukaemia (ALL) | cell differentiation | immunology | membrane signalling

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