Understanding the regulation of the location of chromosomes within the nucleus

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1035229

Funding Status
Closed

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Funded Activity Summary

The nucleus of each human cell, despite being under 10µM in diameter, contains 46 chromosomes, each consisting of several centimeters of DNA. The organisation of chromosomes within the nucleus helps regulate which genes are switched on and off. Genes attached to the nuclear lamina, which lines the nuclear membrane, tend to be switched off. Mutations in the nuclear lamina cause several diseases, including progeria, resulting premature aging. I am interested in understanding why only certain regions of the genome attach to the nuclear lamina.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2018

Funding Scheme: Early Career Fellowships

Funding Amount: $333,612.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genome Structure and Regulation

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

chromatin structure | chromosomes | differentiation | epigenetics | gene expression | gene regulation | genomics

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