Development of endogenous granulocyte colony stimulating factor (G-CSF) antagonism as a new therapeutic approach to inflammatory disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1034594

Funding Status
Closed

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Funded Activity Summary

Neutrophils play a pivotal role in inflammatory diseases including rheumatoid arthritis (RA). G-CSF is a growth factor that is important to neutrophil survival and function. We have shown that in the absence of G-CSF the incidence and severity of experimental autoimmune arthritis are reduced. We will investigate the mechanisms by which this occurs as well as studying the effects of G-CSF blockade on function and survival of human neutrophils from healthy donors and RA patients.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Career Development Fellowships

Funding Amount: $401,561.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autoimmunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antibody therapy | arthritis | growth factor therapy | inflammation | neutrophils

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