Characterisation of SRY Macromolecular Complexes to Provide an Enhanced Understanding of Human Genetic Sex Reversal and Embryonic Sex Determination

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1034456

Funding Status
Closed

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Funded Activity Summary

SRY is the most important gene in the determination of human sex. Mutations in the SRY gene that disrupt its ability to interact with other cellular proteins that regulate its function have shown to result in genetic sex reversal. This project will provide a detailed structural profile of the interfaces that are critical for sex determination, provide a molecular basis for XY-genetic sex reversal, and an enhanced understanding of foetal development.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $237,360.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

developmental biology | developmental genetics | interaction | sex determination | sex reversal

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