Impact of phasevarions of non-typeable Haemophilus influenzae on otitis media pathobiology and vaccine development.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1034401

Funding Status
Closed

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Funded Activity Summary

Otitis media (OM), or middle ear infection, is a prevalent pediatric disease worldwide. Haemophilus influenzae causes 40% of acute OM cases, and most chronic OM and recurrent OM. There is a urgent need for vaccines to prevent OM. Our discovery of a novel genetic switch gives new insights into OM and the change from asymptomatic colonization to OM. The role of this switch on virulence in several dominant strains, and the impact on current and future candidates will be studied.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $613,124.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Haemophilus influenzae | bacterial genetics | bacterial pathogenesis | epigenetics | otitis media

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