Understanding the post-transcriptional regulatory roles of the Hu family of RNA-binding proteins using HITS-CLIP

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1033391

Funding Status
Closed

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Funded Activity Summary

Differentiation of embryonic stem cells into differentiated states such as neurons requires complex changes in a cell's post-transcriptional gene regulation. The Hu family of proteins likely plays a critical role in this regulation, as they can bind message untranslated regions and change whether these messages ultimately make protein products or not. In this application we investigate the function of the Hu proteins in regulating specific mRNAs that we have recently identified.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $588,422.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

RNA binding proteins | RNA processing | differentiation | neurodevelopment | sequencing | stem cell biology | zebrafish

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