Cytokine-driven allergic inflammation: characterization of two isoform-specific modes of IL-3 receptor activation and investigation of new receptor-associated signalling partners.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1033368

Funding Status
Closed

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Funded Activity Summary

In asthma, the symptoms are caused by an allergic reaction in the lung orchestrated by immune cells which produce small proteins called cytokines thus stimulating inflammatory cell production. The cytokine IL-3 is critical for the production of basophils which have an important role in the inflammation. The project will investigate the molecular details of how the IL-3 binds to its receptor and stimulates basophil production and reveal new targets for controlling inflammation in asthma.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $620,716.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cytokine receptor | cytokine signalling | protein-protein interaction | signal transduction | structural biology

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