Glucose toxicity-induced activation of the Bcl-2-regulated apoptotic pathway in pancreatic beta cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1032610

Funding Status
Closed

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Funded Activity Summary

High blood glucose or hyperglycaemia is a feature of type 2 diabetes. Hyperglycaemia and fatty acids in the blood can cause damage of the insulin-producing pancreatic beta cells, resulting in worsening of diabetes. We plan to elucidate the pathways in beta cells that are stimulated by high levels of glucose and fatty acids, and to determine if these pathways are turned on in the pancreas of patients with type 2 diabetes, to try and identify targets for new therapies.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $617,238.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bcl-2 | apoptosis | diabetes mellitus | hyperglycaemia | inflammation | islets of Langerhans

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