Phase variable protein glycosylation in bacteria mucosal pathogens and its role in immune evasion

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1031542

Funding Status
Closed

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Funded Activity Summary

The bacterium Haemophilus influenzae is a leading cause of ear infections. Hearing loss from these infections can seriously affect literacy and educational performance. As no vaccine is available, we will research how the bacterium makes the HMW protein that is important in infection. We will study how sugars are added to the surface of this protein so that the bacterium can escape the immune system, its role in related bacteria and how it may be used in a vaccine.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2016

Funding Scheme: Career Development Fellowships

Funding Amount: $409,728.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Haemophilus influenzae | Neisseria meningitidis | chronic obstructive pulmonary disease (COPD) | glycoproteins | immune evasion | mass spectrometry | meningitis | otitis media | phase variation

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