Investigating a role for TAM receptor signaling in demyelination

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1031450

Funding Status
Closed

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Funded Activity Summary

In Multiple Sclerosis brain cells are damaged and myelin is lost in a process known as demyelination. Two proteins, called Gas6 and Protein S, can influence cells involved in MS, by signalling through proteins called TAMs. We have shown that Gas6 can affect the severity of demyelination in mice, and that TAMs can affect the response of cells to interferon-beta, a major MS treatment. We plan to further study the effects of these proteins during demyelination, and their interaction with interferon-beta.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $444,318.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

microglia | multiple sclerosis (MS) | myelination | neurodegenerative disorders | oligodendrocytes

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