The role of angiopoietin-1 in the self-renewal and metastasis of prostate cancer stem cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1031221

Funding Status
Closed

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Funded Activity Summary

Bone metastasis occurs in more than 80% of cases of advanced prostate cancer (PCa), and is the major cause of morbidity and mortality in PCa patients. Understanding why PCa cells preferentially metastasize to bone may lead to the the development of novel therapy for inhibiting PCa metastasis. This project will study how the bone cell-secreted protein angiopoietin-1 promotes the metastasis of PCa cells to bone and whether inactivation of this protein can inhibit PCa bone metastasis.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $558,742.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Solid Tumours

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bone metastasis | epithelial-mesenchymal transition (EMT) | microrna | prostate cancer | stem cells

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