The role of chemokine networks in severe malaria and the control of parasite density

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1031212

Funding Status
Closed

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Funded Activity Summary

Two contributing factors have been identified as the main determinants of severe malaria: high parasite densities and host inflammatory responses. To date it is not clear whether inflammation is a cause or a consequence of high parasite densities. We have identified a new biomarker (IP-10) of disease severity in a malaria-endemic area of Papua New Guinea that is associated with high parasite densities. Here we will decipher the mechanisms by which IP-10 contributes to the development of high parasite burden and severe malaria.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $620,731.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Parasitology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

immunity | infectious diseases | inflammation | malaria | pathogenesis

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