The NF-kB transcription factors c-Rel and RelA control multiple steps in natural CD4 regulatory T cell development

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1029822

Funding Status
Closed

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Funded Activity Summary

An unfortunate consequence of immune function is that occasionally rogue immune cells are produced that attack the host and lead to the development of so-called autoimmune diseases such as arthritis. Normally a white blood cell called a regulatory T cell suppresses these self-reactive immune cells. We have identified factors that govern the generation of regulatory T cells. Understanding how these factors work should permit the development of new strategies to combat autoimmune diseases. ?

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $566,592.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

T cell development | autoimmunity | epigenetics | gene targeting | microarrays | nuclear factor kappa-B (NF-KB) | regulatory T cells | signal transduction | thymus | transcriptional regulation

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